The Physiochip family comprises several microfluidic based culture chambers which aiming to create cell and tissue culture environments that resemble the in-vivo conditions.

Three different chip models are currently availible which permit to generate different culture conditions under controlled flow conditions in a microfluidic environment.

  • The flow chip, designed to carry out experiments under flow conditions. It counts on three independent culture chambers.
  • The gradient chip allows generating oxygen and chemical gradients in in the culture chamber.
  • The transflow chip, which combines de advantages of flow culture and the transwell devices.

Physiochip working in the TEB500 bioreactor

The Physiochip system is designed to be minimise the appearing of bubbles in the flow circuit and can be used without the need of previous experience. To achive the optimal functionality, the chip is encapsulated in a holder which, in addition, constitutes de interface between the micro and the macro scales. The encapsualte removes most of the difficulties posed by the tiny size of the microfluidic devices for cell culture:

  • Easy connection of tubing to access ports
  • One-step cell injection protocol
  • Compatible with most commercially available syringe and peristaltic pumps
  • Straight manipulation and operation

In order to allow sample inspection, the Physiochip is compatible with high-end microscopy and live cell imaging systems

Physiochip configurations

  • Flow chip +

    The Flow Chip is a cell culture chamber optimized for the execution of cell-based assays under flow conditions. It is Read More
  • Gradient chip +

    The Gradient Chip is an easy-to-use cell culture system that permits to generate long-term stable gradient profiles of soluble molecules Read More
  • Transflow chip +

    The TransFlow Chip results from the integration of flow microenvironments with traditional transwell models. The combination of a permeable support Read More
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