The Centennial Challenges Program is NASA's flagship program for technology prize competitions (www.nasa.gov/challenges). The Centennial Challenges Program directly engages the public, academia, and industry in open prize competitions to stimulate innovation in technologies that have benefit to NASA and the nation. The program is an integral part of NASA's Space Technology Mission Directorate, which is innovating, developing, testing, and flying hardware for use in NASA's future missions. For more information about NASA's Space Technology Mission Directorate, visit: http://www.nasa.gov/spacetech . The Centennial Challenges program is seeking input on a Tissue Engineering Challenge being considered for start in 2015. The challenge would challenge competitors to create a thick tissue construct with cells performing functions of one of the four major solid organs (heart, lung, liver, kidney) and remaining alive long enough to advance scientific research capabilities. The purposes of this RFI are: 1) to gather feedback on the competition being considered, 2) to determine the level of interest in potentially competing in this challenge, and 3) to understand the applicability of the technology developed by the competition for other non-government applications. NASA welcomes replies to this RFI from all segments of industry, academia, and government, including associations, innovators, and enthusiasts. This RFI is for informational/planning purposes only and the Government will not be responsible for any cost associated with preparing information in support of this RFI. This RFI is NOT to be construed as a commitment by the government to enter into any agreement or other obligation, or to conduct a Tissue Engineering Challenge. This notice is issued in accordance with the NASA Prize Authority, 51 U.S.C. 20144. Responses may be made available for public review and should not include proprietary information. Submitted information will be shared within NASA and with contractor personnel associated with the NASA Centennial Challenges Program. All responses are for general access by government reviewers. For general information on the NASA Centennial Challenges Program see: http://www.nasa.gov/challenges . The point of contact is Mr. Sam Ortega, Program Manager, Centennial Challenges Program, Marshall Space Flight Center.