2025
- Functional outcome of cell seeded tracheal scaffold after mechanical stress in vitro
- R.J.J. de Wit, D. Tiemessen, E. Oosterwijk, A.F.T.M. Verhagen
- Biomaterials Advances 167 (2025) 214088
- Products involved: TC3
2024
- Mechanical Stimulation and Aligned Poly(ε-caprolactone)−Gelatin Electrospun Scaffolds Promote Skeletal Muscle Regeneration
- Francisco José Calero-Castro, Víctor Manuel Perez-Puyana, Imán Laga, Javier Padillo Ruiz, Alberto Romero, and Fernando de la Portilla de Juan
- ACS Appl. Bio Mater. 2024, 7, 6430−6440
- Products involved: TC3
- Uncovering the relationship between macrophages and polypropylene surgical mesh
- Nicholas T.H. Farr, Victoria L. Workman, Sanad Saad, Sabiniano Roman, Vanessa Hearnden, Christopher R. Chapple, Craig Murdoch, Cornelia Rodenburg, Sheila MacNeil
- Biomaterials Advances 159 (2024) 213800
- Products involved: TC3
- Prospects of emerging 3D bioprinting technologies: major startup companies and regulatory issues for human use—part II
- Prasanta K. Ghosh
- MGM Journal of Medical Sciences 11(2):p 331-339, April-June 2024.
- Products involved: TC3, TEB500
- A dynamically loaded ex vivo model to study neocartilage and integration in human cartilage repair
- Anna Trengove, Lilith M. Caballero Aguilar, Claudia Di Bella, Carmine Onofrillo, Serena Duchi, and Andrea J. O’Connor
- Front Cell Dev Biol. 2024 Sep 30;12:1449015.
- Products involved: TC3
2023
- Fluid shear stress induces a shift from glycolytic to amino acid pathway in human trophoblasts
- Beatrice Anna Brugger, Lena Neuper, Jacqueline Guettler, Désirée Forstner, Stefan Wernitznig, Daniel Kummer, Freya Lyssy, Julia Feichtinger, Julian Krappinger, Amin El‑Heliebi, Lilli Bonstingl, Gerit Moser, Giovanny Rodriguez‑Blanco, Olaf A. Bachkönig, Benjamin Gottschalk, Michael Gruber, Olivia Nonn, Florian Herse, Stefan Verlohren, Hans‑Georg Frank, Nirav Barapatre, Cornelia Kampfer, Herbert Fluhr, Gernot Desoye and Martin Gauster
- Brugger et al. Cell & Bioscience (2023) 13:163
- Products involved: TEB500
- The Role of Mechanical Properties and Structure of Type I Collagen Hydrogels on Colorectal Cancer Cell Migration
- Hector Castro-Abril, Jónathan Heras, Jesús del Barrio, Laura Paz, Clara Alcaine, Marina Pérez Aliácar, Diego Garzón-Alvarado, Manuel Doblaré, and Ignacio Ochoa
- Macro-molecular Bioscience. Volume 23, Issue 10, October 2023, 2300108
- Products involved: TEB1000
- Regulating the formation and extent of crazing through the application of argon plasma surface functionalisation
- Nicholas T.H. Farr
- Polymer Testing 128 (2023) 108244
- Products involved: TC3
- Ex Vivo Placental Explant Flow Culture - Mimicking the Dynamic Conditions In Utero
- Nadja Kupper, Elisabeth Pritz, Monika Siwetz, Jacqueline Guettler, Berthold Huppertz
- J Vis Exp. 2023 Sep 8:(199).
- Products involved: TEB500
- Platelet-derived factors dysregulate placental sphingosine-1-phosphate receptor 2 in human trophoblasts
- Freya Lyssy, Jacqueline Guettler, Beatrice A Brugger, Christina Stern, Désirée Forstner, Olivia Nonn1, Cornelius Fischer, Florian Herse, Stefan Wernitznig, Birgit Hirschmug, Christian Wadsack ,Martin Gauster
- Reproductive Biomedicine Online. Volume 47, Issue 2103215, August 2023
- Products involved: TEB500
- Creation of a decellularized vaginal matrix from healthy human vaginal tissue for potential vagina reconstruction: experimental studies
- Jayson Sueters, Fangxin Xiao, Jan-Paul Roovers, Mark-Bram Bouman, Freek Groenman, Huub Maas, Judith Huirne, Theo Smit
- Int J Surg. 2023 Sep 26;109(12):3905–3918
- Products involved: TC3
2022
- Anti-Sca-1 antibody-functionalized vascular grafts improve vascular regeneration via selective capture of endogenous vascular stem/progenitor cells
- He Wang, Mengmeng Xing, Weiliang Deng, Meng Qian, Fei Wang, Kai Wang, Adam C. Midgley, Qiang Zhao
- Bioactive Materials. Volume 16, October 2022, Pages 433-450
- Products involved: TEB500
- Strain Gradient Programming in 3D Fibrous Hydrogels to Direct Graded Cell Alignment
- Avraham Kolel, Bar Ergaz, Shahar Goren, Oren Tchaicheeyan, and Ayelet Lesman
- Small methods. Volume 7, Issue 1. January 20, 2023, 2201070
- Products involved: TC3
2021
- Modeling Metastatic Colonization in a Decellularized Organ Scaffold-Based Perfusion Bioreactor
- Maria Rafaeva, Edward R. Horton, Adina R.D. Jensen, Chris D. Madsen, Raphael Reuten, Oliver Willacy, Christian B. Brøchner, Thomas H. Jensen, Kamilla Westarp Zornhagen, Marina Crespo, Dina S. Grønseth, Sebastian R. Nielsen, Manja Idorn, Per thor Straten, Kristoffer Rohrberg, Iben Spanggaard, Martin Højgaard, Ulrik Lassen, Janine T. Erler, and Alejandro E. Mayorca-Guiliani
- Adv. Healthcare Mater. 2021, 2100684
- Products involved: Customized cell culture chamber
- Mechanical loading of bioengineered skeletal muscle in vitro recapitulates gene expression signatures of resistance exercise in vivo
- Daniel C. Turner, Piotr P. Gorski, Robert A. Seaborne, Mark Viggars, Mark Murphy, Jonathan C. Jarvis, Neil R.W. Martin, Claire E. Stewart, Adam P. Sharples
- J Cell Physiol. 2021;236:6534–6547
- Products involved: TC3
- Placental Villous Explant Culture 2.0: Flow Culture Allows Studies Closer to the In Vivo Situation
- Nadja Kupper , Elisabeth Pritz, Monika Siwetz, Jacqueline Guettler and Berthold Huppertz
- Int. J. Mol. Sci. 2021, 22, 7464
- Products involved: TEB500
- A novel characterisation approach to reveal the mechano–chemical effects of oxidation and dynamic distension on polypropylene surgical mesh
- Nicholas T. H. Farr, Sabiniano Roman, Jan Schaefer, Antje Quade, Daniel Lester, Vanessa Hearnden, Sheila MacNeil and Cornelia Rodenburg
- RSC Adv., 2021, 11, 34710–34723
- Products involved: TC3
- A mechanobiological model for tumor spheroids evolution: application to glioblastoma
- Ana Carrasco-Mantis, Héctor Castro-Abril, Teodora Randelovic, Ignacio Ochoa, Manuel Doblaré, José A. Sanz-Herrera
- Computers in Biology and Medicine. Volume 159, June 2023, 106897
- Products involved: TEB1000
- Incorporation of Elastin to Improve Polycaprolactone-Based Scaffolds for Skeletal Muscle via Electrospinning
- Victor Perez-Puyana, Paula Villanueva, Mercedes Jiménez-Rosado, Fernando de la Portilla and Alberto Romero
- Polymers 2021, 13, 1501
- Products involved: TC3
- Fabrication of hybrid scaffolds obtained from combinations of PCL with gelatin or collagen via electrospinning for skeletal muscle tissue engineering
- Victor Perez-Puyana, Paul Wieringa, Yaiza Yuste, Fernando de la Portilla, Antonio Guererro, Alberto Romero, Lorenzo Moroni
- J Biomed Mater Res. 2021;109:1600–1612
- Products involved: TC3
- Elastomeric Electrospun Sca olds of a Biodegradable Aliphatic Copolyester Containing PEG-Like Sequences for Dynamic Culture of Human Endothelial Cells
- Luca Fusaro, Chiara Gualandi, Diego Antonioli, Michelina Soccio, Anna Liguori, Michele Laus, Nadia Lotti, Francesca Boccafoschi and Maria Letizia Focarete
- Biomolecules 2020, 10, 1620
- Products involved: TC3
2019
- Tissue-Level Mechanosensitivity: Predicting and Controlling the Orientation of 3D Vascular Networks
- Shira Landau, Avraham Moriel, Ariel Livne, Ming H. Zheng, Eran Bouchbinder, and Shulamit Levenberg
- Nano Lett. 2018, 18, 7698−7708
- Products involved: TC3
- Micro and nanoscale characterization of poly(DL-lactic-co-glycolic acid) films subjected to the L929 cells and the cyclic mechanical load
- Marcin K. Heljak, Maryla Moczulska-Heljak, Emilia Choińska, Adrian Chlanda, Alicja Kosik-Kozioł, Tomasz Jaroszewicz, Jakub Jaroszewicz, Wojciech Swieszkowski
- Micron 115 (2018) 64–72
- Products involved: TC3
- Effect of Cyclic Stretch on Vascular Endothelial Cells and Abdominal Aortic Aneurysm (AAA): Role in the Inflammatory Response.
- Martina Ramella, Giulia Bertozzi, Luca Fusaro, Maria Talmon, Marcello Manfredi, Marta Calvo Catoria, Francesco Casella, Carla Maria Porta, Renzo Boldorini, Luigia Grazia Fresu, Emilio Marengo and Francesca Boccafoschi
- Int. J. Mol. Sci. 2019, 20, 287; doi:10.3390/ijms20020287
- Products involved: TC3
2018
- Micro and nanoscale characterization of poly(DL-lactic-co-glycolic acid) films subjected to the L929 cells and the cyclic mechanical load.
- Marcin K. Heljak, Maryla Moczulska-Heljak, Emilia Choińska, Adrian Chlanda, Alicja Kosik-Kozioł, Tomasz Jaroszewicz, Jakub Jaroszewicz, Wojciech Swieszkowski
- Micron. doi: 10.1016/j.micron.2018.09.004
- Products involved: TC3
- Blocking mechanosensitive ion channels eliminates the effects of applied mechanical loading on chick joint morphogenesis.
- Cristian Parisi, Vikesh V. Chandaria and Niamh C. Nowlan
- Phiolosphical Transactions B. http://dx.doi.org/10.1098/rstb.2017.0317
- Products involved: TC3
- Oscillatory Strain Promotes Vessel Stabilization and Alignment through Fibroblast YAP-Mediated Mechanosensitivity.
- Shira Landau, Shahar Ben-Shaul, and Shulamit Levenberg
- Vascularization. https://onlinelibrary.wiley.com/doi/full/10.1002/advs.201800506
- Products involved: TC3
- Use of a simple in vitro fatigue test to assess materials used in the surgical treatment of stress urinary incontinence and pelvic organ prolapse.
- Sabiniano Roman, Naside Mangir, Lucie Hympanova, Christopher R. Chapple, Jan Deprest, Sheila MacNeil
- Neurourology and urodynamics. https://doi.org/10.1002/nau.23823
- Products involved: TC3
- The Importance of Biophysical and Biochemical Stimuli in Dynamic Skeletal Muscle Models
- Babette Maleiner, Janine Tomasch, Philipp Heher, Oliver Spadiut, Dominik Rünzler, and Christiane Fuchs
- Frontiers in Physiology, 2 August 2018, Volume 9, Article 1130
- Products involved: TC3
2017
- Multiwell capillarity-based microfluidic device for the study of 3D tumour tissue-2D endothelium interactions and drug screening in co-culture models.
- María Virumbrales-Muñoz, José María Ayuso, Marta Olave, Rosa Monge, Diego de Miguel, Luis Martínez-Lostao, Séverine Le Gac, Manuel Doblaré, Ignacio Ochoa, Luis J. Fernandez.
- SCIENTIFIC REPORTS | 7: 11998 | DOI:10.1038/s41598-017-12049-4.
- Products involved: TEB, PhysioChip.
- Review: bioreactor design towards generation of relevant engineered tissues: focus on clinical translation.
- Akhilandeshwari Ravichandran, Yuchun Liu, Swee-Hin Teoh.
- Journal of Tissue Engineering and Regenerative Medicine. DOI: 10.1002/term.2270.
- Products involved: TEB, TC-3.
- Mimicking Exercise in Three-Dimensional Bioengineered Skeletal Muscle to Investigate Cellular and Molecular Mechanisms of Physiological Adaptation.
- Andreas M. Kasper, Daniel C. Turner, Neil R.W. Martin, Adam P. Sharples.
- Journal of Cell Physiology. DOI: 10.1002/jcp.25840.
- Products involved: TC-3.
- Development of a synthetic tissue engineered 3D printed bioceramic-based bone graft with homogenously distributed osteoblasts and mineralizing bone matrix.
- Doaa Adel-Khattab, Francesca Giacomini, Renate Gildenhaar, Georg Berger, Cynthia Gomes, Ulf Linow, Martin Hardt, Barbara Peleska, Jens Günster, Michael Stiller, Alireza Houshmand, Khaled Abdel Ghaffar, Ahmed Gamal, Mohamed EL-Mofty, Christine Knabe.
- J Tissue Eng Regen Med. 2016 Nov 15. doi: 10.1002/term.2362
- Products involved: TEB, P3D.
- Development of a Synthetic Tissue Engineered 3D Printed Calciumalkaliphosphate-Based Bone Graft with Homogenously Distributed Osteoblasts and Mineralizing Bone Matrix In Vitro.
- D. Adel-Khattab, F. Giacomini, B. Peleska, R. Gildenhaar, G. Berger, C. Gomes, U. Linow, M. Hardt, J. Günster, A. Houshmand, M. Stiller, K. Abdel Ghaffar, A. Gamal, M. El-Mofty, C. Knabe.
- Key Engineering Materials, Vol. 720, pp. 82-89, 2017.
- Products involved: TEB, P3D.
2016
- Bone tissue engineering with scaffold-supported perfusion co-cultures of human stem cell-derived osteoblasts and cell line-derived osteoclasts.
- Isil G. Beskardes, Rebecca S. Hayden, Dean L. Glettig, David L. Kaplan, Menemse Gümüsderelioglu.
- Process Biochemistry. http://dx.doi.org/10.1016/j.procbio.2016.05.008
- Products involved: P3D.
- Correlation between porous texture and cell seeding efficiency of gas foaming and microfluidic foaming scaffolds.
- Marco Costantini, Cristina Colosi, Pamela Mozetic, Jakub Jaroszewicz, Alessia Tosato, Alberto Rainer, Marcella Trombetta, Wojciech Swieszkowski, Mariella Dentini, Andrea Barbetta.
- Materials Science and Engineering: C, Volume 62, 1 May 2016, Pages 668–677.
- Products involved: P3D.
- Mechanical triggering of Wnt3a and beta-catenin in 3D bioreactors: The role of frequency and rhythm.
- Máximo-Alberto Díez-Ulloa, Ramiro Couceiro-Otero.
- OAT. DOI: 10.15761/IMM.1000194.
- Products involved: P3D.
- Indirect three-dimensional printing: A method for fabricating polyurethane-urea based cardiac scaffolds.
- R. Hernández-Córdova, D.A. Mathew, R. Balint, H.J. Carrillo-Escalante, J.M. Cervantes-Uc, L.A. Hidalgo-Bastida, F. Hernández-Sánchez.
- Journal of Biomedical Research Materials. Volume 104, Issue 8, August. Pages 1912–1921.
- Products involved: TEB, P3D.
- Characterising the effects of in vitro mechanical stimulation on morphogenesis of developing limb explants.
- Vikesh V. Chandaria, James McGinty, Niamh C. Nowlan.
- Journal of Biomechanics. November 7, 2016. Volume 49, Issue 15, Pages 3635–3642.
- Products involved: TC-3.
- Developing Repair Materials for Stress Urinary Incontinence to Withstand Dynamic Distension.
- Christopher J. Hillary, Sabiniano Roman, Anthony J. Bullock, Nicola H Green, Christopher R. Chapple, Sheila MacNeil.
- PLOS ONE. http://dx.doi.org/10.1371/journal.pone.0149971.
- Products involved: TC-3.
- Engineering a 3D cardiac patch through cardiomyogenic differentiation of rMSCs by synchronous mechanical and electrical stimulations.
- Kezban Ulubayram, Sukru Ozturk, Reza Shahbazi and Naciye Dilara Zeybek.
- Frontiers in Bioengineering and Biotechnology. DOI=10.3389/conf.FBIOE.2016.01.00653
- Products involved: TC-3.
- Development and characterization of a microfluidic model of the tumour microenvironment.
- Jose M. Ayuso, María Virumbrales-Muñoz, Alodia Lacueva, Pilar M. Lanuza, Elisa Checa-Chavarria, Pablo Botella, Eduardo Fernández, Manuel Doblare, Simon J. Allison, Roger M. Phillips, Julián Pardo, Luis J. Fernandez and Ignacio Ochoa.
- Scientific Reports 6, Article number: 36086 (2016). doi:10.1038/srep36086
- Products involved: TEB.
- Low cost polymeric on-chip flow sensor with nanoliter resolution.
- Jaione Etxebarria, Javier Berganzo, Jorge Elizalde, Guillermo Llamazares, Luis José Fernández, Aitor Ezkerra.
- Sensors and Actuators B: Chemical Volume 235, 1 November 2016, Pages 188–196
- Products involved: TEB.
- A single short session of media perfusion induces osteogenesis in hBMSCs cultured in porous scaffolds, dependent on cell differentiation stage.
- Filipowska J, Reilly GC, Osyczka AM.
- Biotechnology and Bioengineering. DOI: 10.1002/bit.25937.
- Products involved: P3D, TEB.
- Effects of Estrogen and Phytoestrogen Treatment on an In Vitro Model of Recurrent Stroke on HT22 Neuronal Cell Line.
- Javier Morán, Marcos Perez-Basterrechea, Pablo Garrido, Elena Díaz, Ana Alonso, Jesús Otero, Enrique Colado, Celestino González.
- Cell Mol Neurobiol (2017) 37: 405. doi:10.1007/s10571-016-0372-1
- Products involved: TEB.
- Improved Anti-Tumor Activity of Novel Highly Bioactive Liposome-Bound TRAIL in Breast Cancer Cells.
- De Miguel, Diego; Gallego-Lleyda, Ana; M. Ayuso, José; Pawlak, Aleksandra; Conde, Blanca; Ochoa, Ignacio; J. Fernández, Luis; Anel, Alberto; Martinez-Lostao, Luis.
- Recent Patents on Anti-Cancer Drug Discovery, Volume 11, Number 2, April 2016, pp. 197-214(18)
- Products involved: TEB, PhysioChip.
- TRAIL-coated lipid-nanoparticles overcome resistance to soluble recombinant TRAIL in non-small cell lung cancer cells.
- Diego De Miguel, Ana Gallego-Lleyda, José María Ayuso, Sandra Erviti-Ardanaz, Roberto Pazo-Cid, Celia del Agua, Luis José Fernández, Ignacio Ochoa, Alberto Anel, and Luis Martinez-Lostao.
- Nanotechnology, Volume 27, Number 18
- Products involved: PhysioChip.
- High-order TRAIL oligomer formation in TRAIL-coated lipid nanoparticles enhances DR5 cross-linking and increases antitumour effect against colon cancer.
- Diego De Miguel, Ana Gallego-Lleyda, José María Ayuso, Dolores Pejenaute-Ochoa, Vidal Jarauta, Isabel Marzo, Luis J. Fernández, Ignacio Ochoa, Blanca Conde, Alberto Anel, Luis Martinez-Lostao.
- Cancer letters. December 28, 2016. Volume 383, Issue 2, Pages 250–260
- Products involved: PhysioChip.
- Glioblastoma on a microfluidic chip: Generating pseudopalisades and enhancing aggressiveness through blood vessel obstruction events.
- Jose M. Ayuso, Rosa Monge, Alicia Martínez-González, María Virumbrales-Muñoz Guillermo A. Llamazares, Javier Berganzo, Aurelio Hernández-Laín Jorge Santolaria, Manuel Doblaré, Christopher Hubert, Jeremy N. Rich Pilar Sánchez-Gómez, Víctor M. Pérez-García, Ignacio Ochoa, Luis J. Fernández.
- Neuro Oncology. DOI: https://doi.org/10.1093/neuonc/now230
- Products involved: PhysioChip.
2015
- Development of an implantable synthetic membrane for the treatment of preterm premature rupture of fetal membranes.
- Sabiniano Roman, Anthony J Bullock, Dilly O Anumba, Sheila MacNeil.
- Journal of Biomaterials Applications. Vol 30, Issue 7, 2016.
- Products involved: TC-3.
- Cyclical stretch conditioning of an elastomeric cell-seeded pelvic floor repair material using a closed bioreactor system.
- N. Osman, S. Roman, C. Hillary, A.J. Bullock, C.R. Chapple, S. MacNeil.
- European Urology Supplements. Volume 14, Issue 2, April 2015, Pages e1004-e1004a
- Products involved: TC-3.
- SU-8 based microdevices to study self-induced chemotaxis in 3D microenvironments.
- Jose Maria Ayuso, Rosa Monge, Guillermo A. Llamazares, Marco Moreno, Maria Agirregabiria, Javier Berganzo, Manuel Doblaré, Iñaki Ochoa and Luis J. Fernández.
- Front. Mater., 04 May 2015 | https://doi.org/10.3389/fmats.2015.00037
- Products involved: PhysioChip.
- Study of the Chemotactic Response of Multicellular Spheroids in a Microfluidic Device.
- Jose M. Ayuso, Haneen A. Basheer, Rosa Monge, Pablo Sánchez-Álvarez, Manuel Doblaré, Steven D. Shnyder, Victoria Vinader, Kamyar Afarinkia, Luis J. Fernández, Ignacio Ochoa.
- PLOS ONE. http://dx.doi.org/10.1371/journal.pone.0139515
- Products involved: PhysioChip.
- Application of Tissue Engineering to Pelvic Organ Prolapse and Stress Urinary Incontinence.
- Christopher R. CHAPPLE, Nadir I. OSMAN, Altaf MANGERA, Christopher HILLARY, Sabiniano ROMAN, Anthony BULLOCK, Sheila MACNEIL.
- Lower Urinary Tract Symptoms. Volume 7, Issue 2 May 2015 Pages 63–70
- Products involved: TC-3.
2014
- Dynamic cell culture on glassy crystalline calcium alkali orthophosphates scaffolds.
- MA Lopez-Heredia, R Gildenhaar, G Berger, U Finow, C Gomez, A Houshmand, M Stiller, C Knabe-Ducheyne
- European Cells and Materials Vol. 28. Suppl. 1, 2014 (page 19)
- Products involved: P3D, TEB.
2013
- Bioreactors in tissue engineering—principles, applications and commercial constraints.
- Dr. Jan Hansmann, Florian Groeber, Alexander Kahlig, Claudia Kleinhans, Heike Walles
- Biotechnology Journal. Volume 8, Issue 3 March 2013 Pages 298–307
- Products involved: P3D, TEB.